Topic
10 pieces in this topic.
Comorbidities
This is the off-label corner of the field. The rationale is real, the trials were mixed, and the risk that matters is one you can walk into by eating less: ketoacidosis with a glucose that looks fine.
Comorbidities
Hidradenitis suppurativa and psoriasis both track weight in ways most patients are never told about. If you have either, this is one of the more concrete reasons to be on this medication.
Comorbidities
Levothyroxine is dosed by body weight, which means your dose was calculated for a body you no longer have. Almost nobody rechecks, and the symptoms of getting it wrong look exactly like the drug working.
Comorbidities
Long-term weight loss lowers uric acid and reduces gout attacks. Getting there can provoke one, which is a genuinely unfair sequence and an entirely predictable one.
Comorbidities
These are usually presented as rival answers to the same question. In practice they are increasingly used in sequence — and the combination that comes up most often is the one nobody planned for: regain, years after an operation.
Comorbidities
Two opposite things are true at once: these drugs protect the kidney over years, and they can injure it in a single bad week. Both belong in the same conversation and they almost never get one.
Comorbidities
Some of the most effective drugs in psychiatry cause substantial weight gain, and the people taking them are routinely told to eat less by clinicians who know perfectly well that is not what is happening.
Comorbidities
Every extra kilogram lands on the knee several times over with each step, which is why the joint that hurts is usually the one carrying the most. There is now a randomised trial for this, and the result is better than most people expect.
Comorbidities
The commonest liver disease in the world has no approved drug for most of the people who have it, and a large share of them are sitting in front of a prescription that treats the thing causing it.
Comorbidities
Tirzepatide now carries an approved indication for obstructive sleep apnea, on the strength of a trial that cut the severity measure by about half. The practical consequence catches people out: your CPAP pressure is now wrong.